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Macaque model for severe acute respiratory syndrome.
Rowe, Thomas; Gao, Guangping; Hogan, Robert J; Crystal, Ronald G; Voss, Thomas G; Grant, Rebecca L; Bell, Peter; Kobinger, Gary P; Wivel, Nelson A; Wilson, James M.
Affiliation
  • Rowe T; 204 Wistar, 3601 Spruce St., Philadelphia, PA 19104. wilsonjm@mail.med.upenn.edu
J Virol ; 78(20): 11401-4, 2004 Oct.
Article in En | MEDLINE | ID: mdl-15452262
ABSTRACT
Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Disease Models, Animal Limits: Animals / Humans Language: En Journal: J Virol Year: 2004 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Disease Models, Animal Limits: Animals / Humans Language: En Journal: J Virol Year: 2004 Document type: Article