Aniline Compounds/chemical synthesis; Pyrimidines/chemical synthesis; Quinazolines/chemical synthesis; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Adenosine Triphosphate/chemistry; Administration, Oral; Aniline Compounds/pharmacokinetics; Aniline Compounds/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Antirheumatic Agents/chemical synthesis; Antirheumatic Agents/pharmacokinetics; Antirheumatic Agents/pharmacology; Binding Sites; Biological Availability; Crystallography, X-Ray; Humans; In Vitro Techniques; Models, Molecular; Protein Binding; Pyrimidines/pharmacokinetics; Pyrimidines/pharmacology; Quinazolines/pharmacokinetics; Quinazolines/pharmacology; Rats; Signal Transduction; Structure-Activity Relationship; Time Factors; p38 Mitogen-Activated Protein Kinases/physiology