Reconstitution of human airway tissue in the humanized xenograft model.
J Cyst Fibros
; 3 Suppl 2: 63-5, 2004 Aug.
Article
in En
| MEDLINE
| ID: mdl-15463929
ABSTRACT
Normal human airway epithelial tissue may be reconstituted in the humanized xenograft model in immunodeficient NUDE mice. Epithelial cells dissociated from human fetal or adult tissue are seeded on a denuded rat trachea and implanted in the NUDE mice. After a first step of dedifferentiation, the human epithelial cells adhere on the denuded basal lamina of the rat host trachea and progressively reconstitute a normal well-differentiated epithelium after several steps of migration, proliferation, stratification and redifferentiation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tracheal Diseases
/
Cell Transplantation
/
Respiratory Mucosa
/
Epithelial Cells
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Cyst Fibros
Year:
2004
Document type:
Article
Affiliation country:
France