The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism.

Santos, Cláudio R; Vega, Francisco M; Blanco, Sandra; Barcia, Ramiro; Lazo, Pedro A

Santos, Cláudio R; Vega, Francisco M; Blanco, Sandra; Barcia, Ramiro; Lazo, Pedro A.

Affiliation

Santos CR; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, E-37007 Salamanca, Spain.

Virology ; 328(2): 254-65, 2004 Oct 25.

Article in En | MEDLINE | ID: mdl-15464845

Subject(s)

Nuclear Proteins/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; Vaccinia virus/metabolism; Viral Proteins/metabolism; Alanine; Amino Acid Substitution; Animals; Cell Line; Down-Regulation; Mice; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-mdm2; Serine; Threonine; Tumor Suppressor Protein p53/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccinia virus / Viral Proteins / Nuclear Proteins / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases Limits: Animals Language: En Journal: Virology Year: 2004 Document type: Article Affiliation country: Spain Country of publication: United States

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