Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.

Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikström, Håkan V; Grol, Cor J

Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikström, Håkan V; Grol, Cor J.

Affiliation

Vermeulen ES; Department of Medicinal Chemistry, Center for Pharmacy, State University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands. e.s.vermeulen@farm.rug.nl

J Med Chem ; 47(22): 5451-66, 2004 Oct 21.

Article in En | MEDLINE | ID: mdl-15481983

Subject(s)

Isoquinolines/chemical synthesis; Piperazines/chemical synthesis; Serotonin Receptor Agonists/chemical synthesis; Sulfonamides/chemical synthesis; Adenylyl Cyclase Inhibitors; Animals; Binding Sites; Cell Line; Humans; Isoquinolines/chemistry; Isoquinolines/pharmacology; Ligands; Models, Molecular; Piperazines/chemistry; Piperazines/pharmacology; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptors, Serotonin/chemistry; Receptors, Serotonin/drug effects; Serotonin Receptor Agonists/chemistry; Serotonin Receptor Agonists/pharmacology; Sulfonamides/chemistry; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Sulfonamides / Serotonin Receptor Agonists / Isoquinolines Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: Netherlands

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