Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan, Umut; Cao, Qiong; Yilmaz, Erkan; Lee, Ann-Hwee; Iwakoshi, Neal N; Ozdelen, Esra; Tuncman, Gürol; Görgün, Cem; Glimcher, Laurie H; Hotamisligil, Gökhan S

Ozcan, Umut; Cao, Qiong; Yilmaz, Erkan; Lee, Ann-Hwee; Iwakoshi, Neal N; Ozdelen, Esra; Tuncman, Gürol; Görgün, Cem; Glimcher, Laurie H; Hotamisligil, Gökhan S.

Affiliation

Ozcan U; Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA.

Science ; 306(5695): 457-61, 2004 Oct 15.

Article in En | MEDLINE | ID: mdl-15486293

Subject(s)

Diabetes Mellitus, Type 2/metabolism; Endoplasmic Reticulum/metabolism; Insulin Resistance; Insulin/metabolism; Obesity/metabolism; Adipose Tissue/metabolism; Animals; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Glucose/metabolism; Homeostasis; Insulin Receptor Substrate Proteins; Liver/metabolism; Membrane Proteins/metabolism; Mice; Mice, Inbred BALB C; Mice, Obese; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases/metabolism; Muscle, Skeletal/metabolism; Mutation; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phosphoproteins/metabolism; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Rats; Receptor, Insulin/metabolism; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors; Tunicamycin/pharmacology; X-Box Binding Protein 1; eIF-2 Kinase/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Diabetes Mellitus, Type 2 / Endoplasmic Reticulum / Insulin / Obesity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Science Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links