A phase I and pharmacology study of GR63178A, a water-soluble analogue of mitoquidone.

Eccles, D M; Cummings, J; Stewart, M E; Nicolson, M; Cornbleet, M A; Leonard, R C; Smyth, J F

Eccles, D M; Cummings, J; Stewart, M E; Nicolson, M; Cornbleet, M A; Leonard, R C; Smyth, J F.

Affiliation

Eccles DM; Medical Oncology Unit, Western General Hospital, Edinburgh, U.K.

Cancer Chemother Pharmacol ; 29(5): 375-8, 1992.

Article in En | MEDLINE | ID: mdl-1551176

Subject(s)

Antineoplastic Agents/adverse effects; Isoquinolines/adverse effects; Organophosphorus Compounds/adverse effects; Adult; Aged; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/analysis; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Isoquinolines/administration & dosage; Isoquinolines/analysis; Isoquinolines/pharmacokinetics; Isoquinolines/pharmacology; Middle Aged; Neoplasms/drug therapy; Neoplasms/metabolism; Organophosphorus Compounds/administration & dosage; Organophosphorus Compounds/analysis; Organophosphorus Compounds/pharmacokinetics; Organophosphorus Compounds/pharmacology; Solubility; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Isoquinolines / Antineoplastic Agents Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Cancer Chemother Pharmacol Year: 1992 Document type: Article Affiliation country: United kingdom Country of publication: Germany

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