[Influence of human genetic variants on resistance and immunity against malaria]. / Einfluss genetischer Varianten des Menschen auf Resistenz und Immunität gegen Malaria.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
; 47(10): 1000-8, 2004 Oct.
Article
in De
| MEDLINE
| ID: mdl-15521114
ABSTRACT
Certain human genetic variants occur on-ly in areas endemic for malaria. They protect against fatal malaria complications and cause inhibition of growth or development of malaria parasites in vitro. Among these are the haemoglobins (Hb) S and C, alpha-thalassaemias, glucose-6-phosphate dehydrogenase deficiency, as well as a deletion in the erythrocyte band 3 protein. Evidence for similar effects has been obtained for HbD and HbE, glycophorins A and C as well as for a number of immunologically relevant molecules such as human leukocyte antigens,tumour-necrosis-factor a and the inducible nitric oxide synthase. The findings indicate that malaria in endemic areas has caused a substantial selection of the human genome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Malaria, Falciparum
Limits:
Humans
Language:
De
Journal:
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Journal subject:
SAUDE PUBLICA
Year:
2004
Document type:
Article
Publication country:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY