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Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats.
Liu, Lin; Igarashi, Kaoru; Haruyama, Naoto; Saeki, Shuichi; Shinoda, Hisashi; Mitani, Hideo.
Affiliation
  • Liu L; Tohoku University Graduate School of Dentistry, Sendai, Japan.
Eur J Orthod ; 26(5): 469-73, 2004 Oct.
Article in En | MEDLINE | ID: mdl-15536834
ABSTRACT
Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.
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Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Root Resorption / Tooth Movement Techniques / Clodronic Acid / Alveolar Process Limits: Animals Language: En Journal: Eur J Orthod Year: 2004 Document type: Article Affiliation country: Japan
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Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Root Resorption / Tooth Movement Techniques / Clodronic Acid / Alveolar Process Limits: Animals Language: En Journal: Eur J Orthod Year: 2004 Document type: Article Affiliation country: Japan
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