Evidence for pteridine regulation of lead-mediated inhibition of uroporphyrinogen and heme formation in rat bone marrow.

Christenson, W R; Bestervelt, L L; Piper, W N

Christenson, W R; Bestervelt, L L; Piper, W N.

Affiliation

Christenson WR; Department of Pharmacology, University of Nebraska Medical Center, Omaha 68105.

Toxicol Appl Pharmacol ; 113(1): 138-43, 1992 Mar.

Article in En | MEDLINE | ID: mdl-1553748

Subject(s)

Bone Marrow/drug effects; Heme/biosynthesis; Lead/toxicity; Pteridines/metabolism; Pteroylpolyglutamic Acids/deficiency; Uroporphyrinogens/biosynthesis; 7-Alkoxycoumarin O-Dealkylase/metabolism; Animals; Bone Marrow/enzymology; Bone Marrow/metabolism; Drug Synergism; Heme Oxygenase (Decyclizing)/metabolism; Injections, Intraperitoneal; Male; Microsomes/enzymology; Microsomes/metabolism; Nitrous Oxide/toxicity; Protoporphyrins/biosynthesis; Protoporphyrins/isolation & purification; Pteroylpolyglutamic Acids/analysis; Rats; Rats, Inbred Strains; Uroporphyrinogen III Synthetase/metabolism; Uroporphyrinogens/isolation & purification

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Collection: 01-internacional Database: MEDLINE Main subject: Pteridines / Uroporphyrinogens / Bone Marrow / Pteroylpolyglutamic Acids / Heme / Lead Type of study: Prognostic_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 1992 Document type: Article

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