Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

Pringle, Märit; Poehlsgaard, Jacob; Vester, Birte; Long, Katherine S

Pringle, Märit; Poehlsgaard, Jacob; Vester, Birte; Long, Katherine S.

Affiliation

Pringle M; Department of Antibiotics, National Veterinary Institute, SE-75189 Uppsala, Sweden.

Mol Microbiol ; 54(5): 1295-306, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15554969

Subject(s)

Diterpenes/pharmacology; Drug Resistance, Bacterial/genetics; Mutation; RNA, Ribosomal, 23S/genetics; Ribosomal Proteins/genetics; Spirochaetales/drug effects; Amino Acid Substitution; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/genetics; Base Sequence; DNA Mutational Analysis; Diterpenes/metabolism; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Protein Synthesis Inhibitors/pharmacology; RNA, Bacterial/genetics; Ribosomal Protein L3; Spirochaetales/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Ribosomal Proteins / Spirochaetales / RNA, Ribosomal, 23S / Drug Resistance, Bacterial / Diterpenes / Mutation Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Mol Microbiol Journal subject: BIOLOGIA MOLECULAR / MICROBIOLOGIA Year: 2004 Document type: Article Affiliation country: Sweden

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