Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively.

Porta, Chiara; Hadj-Slimane, Reda; Nejmeddine, Mohamed; Pampin, Mathieu; Tovey, Michael G; Espert, Lucile; Alvarez, Sandra; Chelbi-Alix, Mounira K

Porta, Chiara; Hadj-Slimane, Reda; Nejmeddine, Mohamed; Pampin, Mathieu; Tovey, Michael G; Espert, Lucile; Alvarez, Sandra; Chelbi-Alix, Mounira K.

Affiliation

Porta C; UPR CNRS 9045, Institut André Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France.

Oncogene ; 24(4): 605-15, 2005 Jan 20.

Article in En | MEDLINE | ID: mdl-15580300

Subject(s)

Apoptosis/drug effects; Interferon-alpha/pharmacology; Interferon-gamma/pharmacology; Signal Transduction/drug effects; Tumor Suppressor Protein p53/metabolism; Cell Line, Tumor; Cell Nucleus/metabolism; DNA-Binding Proteins/metabolism; Humans; Interferon Regulatory Factor-1; Neoplasm Proteins/metabolism; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/pathology; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phosphoproteins/metabolism; Promyelocytic Leukemia Protein; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-mdm2; Transcription Factors/metabolism; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Proteins; Up-Regulation/drug effects; fas Receptor/genetics; fas Receptor/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Protein p53 / Interferon-gamma / Interferon-alpha / Apoptosis Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2005 Document type: Article Affiliation country: France Country of publication: United kingdom

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