T-box genes and heart development: putting the "T" in heart.
Dev Dyn
; 232(1): 11-20, 2005 Jan.
Article
in En
| MEDLINE
| ID: mdl-15580613
ABSTRACT
Members of the T-box gene family (Tbx) are essential for normal heart development, and mutations in human TBX genes cause congenital cardiovascular malformations. T-box genes have been implicated in early cardiac lineage determination, chamber specification, valvuloseptal development, and diversification of the specialized conduction system in vertebrate embryos. These genes include Tbx1, Tbx2, Tbx3, Tbx5, Tbx18, and Tbx20, all of which exhibit complex temporal spatial regulation in developing cardiac structures. Less is known about T-box genes in invertebrate heart development, but multiple T-box genes are expressed in Drosophila cardiac lineages. The molecular hierarchies and developmental processes controlled by T-box genes in the heart are the focus of this review.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular System
/
Gene Expression Regulation, Developmental
/
T-Box Domain Proteins
/
Heart
/
Myocardium
Limits:
Animals
/
Humans
Language:
En
Journal:
Dev Dyn
Journal subject:
ANATOMIA
Year:
2005
Document type:
Article
Affiliation country:
United States