IFN-beta treatment modulates the CD28/CTLA-4-mediated pathway for IL-2 production in patients with relapsing-remitting multiple sclerosis.
Mult Scler
; 10(6): 630-5, 2004 Dec.
Article
in En
| MEDLINE
| ID: mdl-15584487
ABSTRACT
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system probably mediated by Th1 lymphocytes. IFN-beta is an established therapy for relapsing MS patients, although the mechanisms underlying its efficacy are yet to be well characterized. We determined IL-2 production, CD25 expression and T-cell proliferation from relapsing-remitting MS patients before and three months after starting therapy. A decrease in the percentage of CD80-induced IL-2-producing cells was observed after in vivo IFN-beta treatment. These data support that one of the immunomodulatory effects of IFN-beta treatment in MS may be a limitation of the autoimmune response modifying the CD80CD28/CTLA-4 pathway.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antigens, Differentiation
/
Adjuvants, Immunologic
/
Interleukin-2
/
Interferon-beta
/
CD28 Antigens
/
Multiple Sclerosis, Relapsing-Remitting
Type of study:
Clinical_trials
Limits:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Spain