Do cancers invade veins?
Arch Surg
; 127(4): 389-91, 1992 Apr.
Article
in En
| MEDLINE
| ID: mdl-1558489
ABSTRACT
It is postulated that all malignant tumors spread in the same way. They invade through the basement membrane, spread through the interstitial compartment for variable distances, enter a lymphatic vessel through natural clefts, and reach the vascular compartment through lymphatic venous anastomoses or terminal lymphatics. The brain would seem to be an ideal site to test these ideas since it contains no lymphatic vessels. Injections of a well-characterized murine mammary tumor into the brains of 123 mice resulted in growth of the tumor in 82 mice (67%). Autopsy revealed only five cases in which there was distant tumor that had invaded beyond the brain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Veins
/
Brain Neoplasms
/
Mammary Neoplasms, Experimental
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
Limits:
Animals
Language:
En
Journal:
Arch Surg
Year:
1992
Document type:
Article