A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense.

Fessler, Michael B; Young, Scott K; Jeyaseelan, Samithamby; Lieber, Jonathan G; Arndt, Patrick G; Nick, Jerry A; Worthen, G Scott

Fessler, Michael B; Young, Scott K; Jeyaseelan, Samithamby; Lieber, Jonathan G; Arndt, Patrick G; Nick, Jerry A; Worthen, G Scott.

Affiliation

Fessler MB; Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA. michael.fessler@uchsc.edu

Am J Respir Crit Care Med ; 171(6): 606-15, 2005 Mar 15.

Article in En | MEDLINE | ID: mdl-15591471

Subject(s)

Hydroxymethylglutaryl CoA Reductases/physiology; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Lovastatin/pharmacology; Lung/immunology; Pneumonia/etiology; Pneumonia/immunology; Actins/metabolism; Animals; Bronchoalveolar Lavage Fluid/immunology; Cell Communication; Chemokines; Chemotaxis; Female; Humans; Klebsiella pneumoniae; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophils/immunology; Pneumonia, Bacterial/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Lovastatin / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hydroxymethylglutaryl CoA Reductases / Lung Limits: Animals / Female / Humans Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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