Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.

Hosoda, Chihiro; Koshimizu, Taka-Aki; Tanoue, Akito; Nasa, Yoshihisa; Oikawa, Ryo; Tomabechi, Takashi; Fukuda, Shinya; Shinoura, Hitomi; Oshikawa, Sayuri; Takeo, Satoshi; Kitamura, Tadaichi; Cotecchia, Susanna; Tsujimoto, Gozoh

Hosoda, Chihiro; Koshimizu, Taka-Aki; Tanoue, Akito; Nasa, Yoshihisa; Oikawa, Ryo; Tomabechi, Takashi; Fukuda, Shinya; Shinoura, Hitomi; Oshikawa, Sayuri; Takeo, Satoshi; Kitamura, Tadaichi; Cotecchia, Susanna; Tsujimoto, Gozoh.

Affiliation

Hosoda C; Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Mol Pharmacol ; 67(3): 912-22, 2005 Mar.

Article in En | MEDLINE | ID: mdl-15598970

Subject(s)

Blood Pressure/drug effects; Receptors, Adrenergic, alpha-1/physiology; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/physiology; Blood Pressure/physiology; Cloning, Molecular; Heart Rate/drug effects; Heart Rate/physiology; In Vitro Techniques; Mice; Mice, Knockout; Potassium Chloride/pharmacology; Prazosin/pharmacokinetics; Radioligand Assay; Receptors, Adrenergic, alpha-1/deficiency; Receptors, Adrenergic, alpha-1/drug effects; Receptors, Adrenergic, alpha-1/genetics; Recombinant Proteins/drug effects; Recombinant Proteins/metabolism; Vasoconstriction/drug effects; Vasoconstriction/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Pressure / Receptors, Adrenergic, alpha-1 Limits: Animals Language: En Journal: Mol Pharmacol Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United States

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