Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet-derived growth factor-BB.

Dang, Ian; DeVries, George H

Dang, Ian; DeVries, George H.

Affiliation

Dang I; Research Service, Hines VA Hospital, Hines, IL 60141, USA. george.devries@med.va.gov

J Neurosci Res ; 79(3): 318-28, 2005 Feb 01.

Article in En | MEDLINE | ID: mdl-15602756

Subject(s)

Calcium Signaling/physiology; Nerve Sheath Neoplasms/metabolism; Neurofibromatosis 1/metabolism; Platelet-Derived Growth Factor/pharmacology; Receptor, Platelet-Derived Growth Factor beta/metabolism; Schwann Cells/metabolism; Adult; Becaplermin; Calcium/metabolism; Calcium Signaling/drug effects; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cell Line; Cell Transformation, Neoplastic/drug effects; Enzyme Inhibitors/pharmacology; Female; Humans; MAP Kinase Signaling System/physiology; Male; Middle Aged; Nerve Sheath Neoplasms/drug therapy; Nerve Sheath Neoplasms/physiopathology; Neurofibromatosis 1/physiopathology; Neurofibromin 1/biosynthesis; Phosphorylation/drug effects; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Receptor, Platelet-Derived Growth Factor beta/drug effects; Schwann Cells/drug effects; Schwann Cells/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Schwann Cells / Platelet-Derived Growth Factor / Neurofibromatosis 1 / Nerve Sheath Neoplasms / Calcium Signaling / Receptor, Platelet-Derived Growth Factor beta Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Neurosci Res Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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