BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.

Tertyshnikova, Svetlana; Knox, Ronald J; Plym, Mary Jane; Thalody, George; Griffin, Corinne; Neelands, Torben; Harden, David G; Signor, Laura; Weaver, David; Myers, Robert A; Lodge, Nicholas J

Tertyshnikova, Svetlana; Knox, Ronald J; Plym, Mary Jane; Thalody, George; Griffin, Corinne; Neelands, Torben; Harden, David G; Signor, Laura; Weaver, David; Myers, Robert A; Lodge, Nicholas J.

Affiliation

Tertyshnikova S; Neuroscience Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Neuroscience Drug Discovery, 5 Research Parkway, Wallingford, CT 06492-7660, USA. svetlana.tertyshnikova@bms.com

J Pharmacol Exp Ther ; 313(1): 250-9, 2005 Apr.

Article in En | MEDLINE | ID: mdl-15608074

Subject(s)

Muscle, Smooth/drug effects; Potassium Channels/agonists; Tetrahydronaphthalenes/pharmacology; Tetrazoles/pharmacology; Urinary Bladder/drug effects; Anesthesia; Animals; Barium/pharmacology; Blood Pressure/drug effects; Humans; Male; Membrane Potentials/drug effects; Myocytes, Cardiac/drug effects; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

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Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydronaphthalenes / Tetrazoles / Urinary Bladder / Potassium Channels / Muscle, Smooth Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2005 Document type: Article Affiliation country: United States

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