Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator.

Sprague, Jennifer E; Peng, Yijie; Sun, Xiankai; Weisman, Gary R; Wong, Edward H; Achilefu, Samuel; Anderson, Carolyn J

Sprague, Jennifer E; Peng, Yijie; Sun, Xiankai; Weisman, Gary R; Wong, Edward H; Achilefu, Samuel; Anderson, Carolyn J.

Affiliation

Sprague JE; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Clin Cancer Res ; 10(24): 8674-82, 2004 Dec 15.

Article in En | MEDLINE | ID: mdl-15623652

Subject(s)

Chelating Agents; Copper Radioisotopes; Organometallic Compounds/chemical synthesis; Pancreatic Neoplasms/drug therapy; Radiopharmaceuticals/chemical synthesis; Animals; Binding, Competitive; Chelating Agents/chemistry; Chelating Agents/metabolism; Copper/chemistry; Copper/metabolism; In Vitro Techniques; Organometallic Compounds/chemistry; Organometallic Compounds/pharmacokinetics; Pancreatic Neoplasms/diagnostic imaging; Pancreatic Neoplasms/metabolism; Radiopharmaceuticals/chemistry; Radiopharmaceuticals/pharmacokinetics; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Pancreatic Neoplasms / Copper Radioisotopes / Chelating Agents / Radiopharmaceuticals Type of study: Evaluation_studies Limits: Animals Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2004 Document type: Article Affiliation country: United States

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