Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis.
Neurology
; 63(12): 2381-3, 2004 Dec 28.
Article
in En
| MEDLINE
| ID: mdl-15623705
Antibodies against native glycosylated myelin-oligodendrocyte-glycoprotein (MOG) were measured by ELISA in patients with multiple sclerosis (MS) and controls. Anti-MOG IgM antibodies were elevated during the first demyelinating event. Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantibodies
/
Immunoglobulin G
/
Immunoglobulin M
/
Protein Processing, Post-Translational
/
Myelin-Associated Glycoprotein
/
Multiple Sclerosis, Chronic Progressive
/
Multiple Sclerosis, Relapsing-Remitting
Limits:
Adult
/
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurology
Year:
2004
Document type:
Article
Affiliation country:
Germany
Country of publication:
United States