Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
Org Lett
; 7(2): 311-4, 2005 Jan 20.
Article
in En
| MEDLINE
| ID: mdl-15646985
ABSTRACT
[Structure see text] The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (+)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamate were defined, exploiting two synthetically simplified scaffolds, as well as the parent (+)-discodermolide framework.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrones
/
Carbamates
/
Alkanes
/
Lactones
Limits:
Humans
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2005
Document type:
Article
Affiliation country:
United States