Isolation of an amikacin-resistant Escherichia coli strain after tobramycin treatment of previous recurrent episodes of respiratory tract infections caused by Pseudomonas aeruginosa.

Ruiz, J; Bertran, S; Sauca, G; Julià, A; Vila, X; Gómez, E; Jiménez de Anta, M T; Vila, J

Ruiz, J; Bertran, S; Sauca, G; Julià, A; Vila, X; Gómez, E; Jiménez de Anta, M T; Vila, J.

Affiliation

Ruiz J; Servei de Microbiologia, Hospital Clínic, Villarroel, Barcelona, Spain.

Clin Microbiol Infect ; 11(1): 71-3, 2005 Jan.

Article in En | MEDLINE | ID: mdl-15649309

ABSTRACT

ABSTRACT

Amikacin-resistant Escherichia coli strains are isolated rarely from clinical samples. In the present study, investigation of an amikacin-resistant clinical isolate of E. coli demonstrated the presence of two class 1 integrons carrying the aacA4 gene plus the aacA7 gene, and the dfrA17 gene plus the aadA5 gene, respectively. Resistance to amikacin in this E. coli isolate was related to the presence of both aacA4 and aacA7.

Subject(s)

Amikacin/pharmacology; Anti-Bacterial Agents/pharmacology; Drug Resistance, Bacterial; Escherichia coli Proteins/genetics; Escherichia coli/drug effects; Escherichia coli/isolation & purification; Amikacin/therapeutic use; Anti-Bacterial Agents/therapeutic use; Drug Resistance, Bacterial/genetics; Escherichia coli/genetics; Escherichia coli Infections/drug therapy; Escherichia coli Infections/microbiology; Humans; Integrons/genetics; Microbial Sensitivity Tests; Pseudomonas Infections/drug therapy; Pseudomonas Infections/microbiology; Pseudomonas aeruginosa/drug effects; Recurrence; Respiratory Tract Infections/drug therapy; Respiratory Tract Infections/microbiology; Tobramycin/pharmacology; Tobramycin/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Amikacin / Escherichia coli Proteins / Drug Resistance, Bacterial / Escherichia coli / Anti-Bacterial Agents Limits: Humans Language: En Journal: Clin Microbiol Infect Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2005 Document type: Article Affiliation country: Spain

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