Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human beta3-adrenergic receptor agonists with high cell permeability.

Mizuno, Kazuhiro; Sawa, Masaaki; Harada, Hiroshi; Taoka, Ikuko; Yamashita, Haruhisa; Oue, Mayumi; Tsujiuchi, Hiroshi; Arai, Yukiyo; Suzuki, Shinya; Furutani, Yasuji; Kato, Shiro

Mizuno, Kazuhiro; Sawa, Masaaki; Harada, Hiroshi; Taoka, Ikuko; Yamashita, Haruhisa; Oue, Mayumi; Tsujiuchi, Hiroshi; Arai, Yukiyo; Suzuki, Shinya; Furutani, Yasuji; Kato, Shiro.

Affiliation

Mizuno K; Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd, 33-94, Enoki, Suita 564-0053, Japan. kazuhiro-mizuno@dainippon-pharm.co.jp

Bioorg Med Chem ; 13(3): 855-68, 2005 Feb 01.

Article in En | MEDLINE | ID: mdl-15653351

Subject(s)

Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists/pharmacology; Cell Membrane Permeability; Indoles/pharmacology; Adrenergic beta-Agonists/chemistry; Adrenergic beta-Agonists/metabolism; Caco-2 Cells; Humans; Indoles/chemistry; Indoles/metabolism; Magnetic Resonance Spectroscopy; Radioligand Assay; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Membrane Permeability / Adrenergic beta-Agonists / Adrenergic beta-3 Receptor Agonists / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Document type: Article Affiliation country: Japan

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