Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors.
Bioorg Med Chem Lett
; 15(3): 699-703, 2005 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-15664840
ABSTRACT
Novel arylthiomethyl morpholines are potent selective norepinephrine reuptake inhibitors (NERIs) and dual serotonin/norepinephrine reuptake inhibitors (SRI/NERIs). The target compounds were prepared using a stereochemically versatile synthesis featuring an aldol condensation as the key step. One enantiomer of the 2-methoxy-substituted analogue was found to be a potent and selective norepinephrine reuptake inhibitor, whereas the opposite enantiomer was a potent dual serotonin/norepinephrine reuptake inhibitor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Norepinephrine
/
Morpholines
/
Selective Serotonin Reuptake Inhibitors
/
Adrenergic Uptake Inhibitors
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2005
Document type:
Article
Affiliation country:
United kingdom