Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.

Quinney, S K; Sanghani, S P; Davis, W I; Hurley, T D; Sun, Z; Murry, D J; Bosron, W F

Quinney, S K; Sanghani, S P; Davis, W I; Hurley, T D; Sun, Z; Murry, D J; Bosron, W F.

Affiliation

Quinney SK; Department of Pharmacy Practice, Purdue University, Indianapolis, IN 46202, USA. wbosron@iupui.edu

J Pharmacol Exp Ther ; 313(3): 1011-6, 2005 Jun.

Article in En | MEDLINE | ID: mdl-15687373

Subject(s)

Antimetabolites, Antineoplastic/metabolism; Carboxylesterase/metabolism; Deoxycytidine/analogs & derivatives; Deoxycytidine/metabolism; Isoenzymes/metabolism; Loperamide/pharmacology; Prodrugs/metabolism; Capecitabine; Carboxylesterase/antagonists & inhibitors; Carboxylesterase/genetics; Fluorouracil/analogs & derivatives; Gastrointestinal Tract/enzymology; Humans; Hydrolysis; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Carboxylesterase / Deoxycytidine / Isoenzymes / Loperamide / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: J Pharmacol Exp Ther Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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