Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.

Imaoka, Tatsuhiko; Nishimura, Mayumi; Teramoto, Ayako; Nishimura, Yukiko; Ootawara, Masami; Osada, Harumi; Kakinuma, Shizuko; Maekawa, Akihiko; Shimada, Yoshiya

Imaoka, Tatsuhiko; Nishimura, Mayumi; Teramoto, Ayako; Nishimura, Yukiko; Ootawara, Masami; Osada, Harumi; Kakinuma, Shizuko; Maekawa, Akihiko; Shimada, Yoshiya.

Affiliation

Imaoka T; Research Center for Radiation Safety, National Institute of Radiological Sciences, Anagawa, Chiba, Japan.

Int J Cancer ; 115(2): 187-93, 2005 Jun 10.

Article in En | MEDLINE | ID: mdl-15688392

Subject(s)

Adenocarcinoma/metabolism; Gamma Rays; Genes, ras/genetics; Mammary Neoplasms, Experimental/metabolism; Mutation/genetics; Proto-Oncogene Proteins c-myc/metabolism; Adenocarcinoma/etiology; Adenocarcinoma/pathology; Alkylating Agents/toxicity; Animals; Cocarcinogenesis; Female; Fibroadenoma/etiology; Fibroadenoma/pathology; Humans; Incidence; Mammary Neoplasms, Experimental/etiology; Mammary Neoplasms, Experimental/pathology; Methylnitrosourea/toxicity; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival Rate

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Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Proto-Oncogene Proteins c-myc / Genes, ras / Gamma Rays / Mammary Neoplasms, Experimental / Mutation Type of study: Etiology_studies / Incidence_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2005 Document type: Article Affiliation country: Japan

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