Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms.

Grigoryants, Vladimir; Hannawa, Kevin K; Pearce, Charles G; Sinha, Indranil; Roelofs, Karen J; Ailawadi, Gorav; Deatrick, Kristopher B; Woodrum, Derek T; Cho, Brenda S; Henke, Peter K; Stanley, James C; Eagleton, Matthew J; Upchurch, Gilbert R

Grigoryants, Vladimir; Hannawa, Kevin K; Pearce, Charles G; Sinha, Indranil; Roelofs, Karen J; Ailawadi, Gorav; Deatrick, Kristopher B; Woodrum, Derek T; Cho, Brenda S; Henke, Peter K; Stanley, James C; Eagleton, Matthew J; Upchurch, Gilbert R.

Affiliation

Grigoryants V; Jobst Vascular Research Laboratory, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

J Vasc Surg ; 41(1): 108-14, 2005 Jan.

Article in En | MEDLINE | ID: mdl-15696052

Subject(s)

Aortic Aneurysm, Abdominal/prevention & control; Catalase/biosynthesis; Neutrophil Infiltration/drug effects; Selective Estrogen Receptor Modulators/pharmacology; Tamoxifen/pharmacology; Amitrole/pharmacology; Animals; Catalase/antagonists & inhibitors; Immunohistochemistry; Male; Matrix Metalloproteinase 9/analysis; Pancreatic Elastase/pharmacology; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators/administration & dosage; Tamoxifen/administration & dosage; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Catalase / Aortic Aneurysm, Abdominal / Selective Estrogen Receptor Modulators / Neutrophil Infiltration Limits: Animals Language: En Journal: J Vasc Surg Journal subject: ANGIOLOGIA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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