Craniofacial dysmorphology in Swedish schizophrenia patients.
Acta Psychiatr Scand
; 111(3): 202-7, 2005 Mar.
Article
in En
| MEDLINE
| ID: mdl-15701104
ABSTRACT
OBJECTIVE:
To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia.METHOD:
We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n=24), healthy controls (n=16), and patients' siblings with schizophrenia (n=2) in Sweden, while remaining as blind as possible to schizophrenia/control status.RESULTS:
Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status.CONCLUSION:
The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Craniofacial Abnormalities
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Acta Psychiatr Scand
Year:
2005
Document type:
Article
Affiliation country:
Ireland