Alendronate in the treatment of low bone mass in steroid-treated boys with Duchennes muscular dystrophy.
Arch Phys Med Rehabil
; 86(2): 284-8, 2005 Feb.
Article
in En
| MEDLINE
| ID: mdl-15706555
ABSTRACT
OBJECTIVE:
To examine alendronates side-effect profile and effect on bone mineral density (BMD) in deflazacort-treated boys with Duchennes muscular dystrophy (DMD) and low BMD.DESIGN:
Before-after trial.SETTING:
Neuromuscular clinic at a children's hospital in Canada between 1999 and 2000.PARTICIPANTS:
All consenting boys with DMD who had z scores less than -1.00 (spine and/or total body) and in whom BMD testing was feasible. INTERVENTION Boys received .08 mg.kg(-1) .d(-1) of alendronate orally, with 750 mg of daily calcium and 1000 IU of vitamin D. BMD, height, weight, physical activity, Tanner stage, and adverse effects were followed for 2 years. MAIN OUTCOMEMEASURES:
BMD z scores at the lumbar spine (L1-4) and total body.RESULTS:
Of the 42 eligible boys assessed, 23 had low BMD; for 16 of the 23, future BMD testing was feasible. Mean age was 10.8 years (range, 6.9-15.6 y). Mean baseline z scores at the total body and spine were -0.80 and -1.94, respectively. At 2 years, mean z scores were unchanged. Furthermore, alendronate response varied by baseline age. In multivariable analysis, improvement in total body and spine z scores was associated with younger age at baseline ( P =.01 for both).CONCLUSIONS:
In deflazacort-treated boys, alendronate had a positive effect on BMD z scores; the effect was greatest when given early in the course of disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnenediones
/
Bone Density
/
Alendronate
/
Muscular Dystrophy, Duchenne
/
Glucocorticoids
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
Arch Phys Med Rehabil
Year:
2005
Document type:
Article
Affiliation country:
Canada