Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells.

Boulanger, Jim; Vézina, Anne; Mongrain, Sébastien; Boudreau, Francois; Perreault, Nathalie; Auclair, Benoît A; Lainé, Jean; Asselin, Claude; Rivard, Nathalie

Boulanger, Jim; Vézina, Anne; Mongrain, Sébastien; Boudreau, Francois; Perreault, Nathalie; Auclair, Benoît A; Lainé, Jean; Asselin, Claude; Rivard, Nathalie.

Affiliation

Boulanger J; Canadian Institutes of Health Research Group on Functional Development and Physiopathology of the Digestive Tract, Département d'Anatomie et Biologie Cellulaire, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

J Biol Chem ; 280(18): 18095-107, 2005 May 06.

Article in En | MEDLINE | ID: mdl-15741163

Subject(s)

Active Transport, Cell Nucleus/physiology; CDC2-CDC28 Kinases/physiology; Homeodomain Proteins/metabolism; Intestinal Mucosa/metabolism; Proteasome Endopeptidase Complex/metabolism; Active Transport, Cell Nucleus/drug effects; Animals; CDC2-CDC28 Kinases/genetics; CDX2 Transcription Factor; Caco-2 Cells; Cricetinae; Cyclin-Dependent Kinase 2; Homeodomain Proteins/genetics; Humans; Intestinal Mucosa/drug effects; Leupeptins/pharmacology; Mice; Phosphorylation/drug effects; Proteasome Endopeptidase Complex/genetics; Proteasome Inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Homeodomain Proteins / Active Transport, Cell Nucleus / CDC2-CDC28 Kinases / Proteasome Endopeptidase Complex / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: Canada Country of publication: United States

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