Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.

Biswal, Bichitra K; Cherney, Maia M; Wang, Meitian; Chan, Laval; Yannopoulos, Constantin G; Bilimoria, Darius; Nicolas, Olivier; Bedard, Jean; James, Michael N G

Biswal, Bichitra K; Cherney, Maia M; Wang, Meitian; Chan, Laval; Yannopoulos, Constantin G; Bilimoria, Darius; Nicolas, Olivier; Bedard, Jean; James, Michael N G.

Affiliation

Biswal BK; Canadian Institutes of Health Research Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

J Biol Chem ; 280(18): 18202-10, 2005 May 06.

Article in En | MEDLINE | ID: mdl-15746101

Subject(s)

Enzyme Inhibitors/pharmacology; Hepacivirus/enzymology; Models, Molecular; RNA-Dependent RNA Polymerase/antagonists & inhibitors; RNA-Dependent RNA Polymerase/chemistry; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Nonstructural Proteins/chemistry; Amino Acid Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Genotype; Hepacivirus/genetics; Molecular Sequence Data; Protein Conformation; RNA-Dependent RNA Polymerase/metabolism; Sequence Homology, Amino Acid; Thiophenes/chemistry; Thiophenes/pharmacology; Viral Nonstructural Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: RNA-Dependent RNA Polymerase / Models, Molecular / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: Canada Country of publication: United States

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