Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.

Nagaoka, I; Kuwahara-Arai, K; Tamura, H; Hiramatsu, K; Hirata, M

Nagaoka, I; Kuwahara-Arai, K; Tamura, H; Hiramatsu, K; Hirata, M.

Affiliation

Nagaoka I; Department of Host Defense and Biochemical Research, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. nagaokai@med.juntendo.ac.jp

Inflamm Res ; 54(2): 66-73, 2005 Feb.

Article in En | MEDLINE | ID: mdl-15750713

Subject(s)

Amino Acid Substitution; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/pharmacology; Bacteria/drug effects; Animals; Cathelicidins; Cell Membrane Permeability/drug effects; Cell Survival/drug effects; Escherichia coli/metabolism; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Humans; Macrophages/physiology; Mice; Monocytes/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Amino Acid Substitution / Antimicrobial Cationic Peptides Limits: Animals / Humans Language: En Journal: Inflamm Res Journal subject: ALERGIA E IMUNOLOGIA / PATOLOGIA Year: 2005 Document type: Article Affiliation country: Japan Country of publication: Switzerland

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