The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.

Tanaka, Yutaka; Tamura, Kouichi; Koide, Yuichi; Sakai, Masashi; Tsurumi, Yuko; Noda, Yoshihiro; Umemura, Masanari; Ishigami, Tomoaki; Uchino, Kazuaki; Kimura, Kazuo; Horiuchi, Masatsugu; Umemura, Satoshi

Tanaka, Yutaka; Tamura, Kouichi; Koide, Yuichi; Sakai, Masashi; Tsurumi, Yuko; Noda, Yoshihiro; Umemura, Masanari; Ishigami, Tomoaki; Uchino, Kazuaki; Kimura, Kazuo; Horiuchi, Masatsugu; Umemura, Satoshi.

Affiliation

Tanaka Y; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

FEBS Lett ; 579(7): 1579-86, 2005 Mar 14.

Article in En | MEDLINE | ID: mdl-15757644

Subject(s)

Adaptor Proteins, Signal Transducing/physiology; Down-Regulation; Myocytes, Cardiac/metabolism; Receptor, Angiotensin, Type 1/metabolism; Adaptor Proteins, Signal Transducing/analysis; Adaptor Proteins, Signal Transducing/genetics; Adenoviridae/genetics; Animals; Cardiomegaly/genetics; Cardiomegaly/metabolism; Cell Size; Cells, Cultured; Genetic Vectors/genetics; Hypertrophy; Immunoprecipitation; Mice; Myocytes, Cardiac/chemistry; Myocytes, Cardiac/cytology; Phosphorylation; Protein Biosynthesis/genetics; Protein Biosynthesis/physiology; Proto-Oncogene Proteins c-fos/genetics; Proto-Oncogene Proteins c-fos/metabolism; RNA, Messenger/analysis; RNA, Messenger/metabolism; Receptor, Angiotensin, Type 1/analysis; Receptor, Angiotensin, Type 1/genetics; Transcription, Genetic; Transfection; p38 Mitogen-Activated Protein Kinases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Down-Regulation / Myocytes, Cardiac / Receptor, Angiotensin, Type 1 / Adaptor Proteins, Signal Transducing Type of study: Risk_factors_studies Limits: Animals Language: En Journal: FEBS Lett Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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