Failure of interleukin-2 to alter systolic blood pressure in Dahl salt-sensitive rats.
Am J Hypertens
; 5(3): 203-4, 1992 Mar.
Article
in En
| MEDLINE
| ID: mdl-1575949
ABSTRACT
The effect of interleukin-2 (IL-2) on systolic blood pressure in Dahl salt-sensitive rats was investigated. The treatment group received human IL-2 injections (5000 units/kg). Control animals received subcutaneous saline injections. Both groups of animals were placed on a diet containing 1.5% sodium the day of the first injection and maintained on that diet for the duration of the study. Systolic blood pressure increased in both the IL-2 treated and the control groups (P = .0001) over 7 weeks. The increase in SBP was the same for both groups (P = .8823 for between group differences). At the end of 7 weeks, when SBP in both groups was elevated to a similar degree, the IL-2 group and the control group were each administered 5000 units/kg of IL-2. SBP in both groups remained elevated, showing no decrease over the next two weeks. These results indicate that perhaps unlike in SHR, IL-2 does not alter systolic blood pressure in Dahl salt-sensitive rats.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Sodium Chloride
/
Interleukin-2
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Am J Hypertens
Journal subject:
ANGIOLOGIA
Year:
1992
Document type:
Article