Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease.

Nikfarjam, L; Kominami, S; Yamazaki, T; Chen, S; Hewer, R; Pra, C Dal; Nakamatsu, T; Betterle, C; Zanchetta, R; Smith, B Rees; Furmaniak, J

Nikfarjam, L; Kominami, S; Yamazaki, T; Chen, S; Hewer, R; Pra, C Dal; Nakamatsu, T; Betterle, C; Zanchetta, R; Smith, B Rees; Furmaniak, J.

Affiliation

Nikfarjam L; Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, 739-8521 Japan.

Eur J Endocrinol ; 152(1): 95-101, 2005 Jan.

Article in En | MEDLINE | ID: mdl-15762192

Subject(s)

Addison Disease/enzymology; Autoantibodies/metabolism; Steroid 21-Hydroxylase/antagonists & inhibitors; Addison Disease/immunology; Carbon Monoxide/pharmacology; Dithionite; Humans; Immunoglobulin G/metabolism; Microsomes/metabolism; NADPH-Ferrihemoprotein Reductase/metabolism; Oxidation-Reduction; Protein Conformation; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/chemistry; Recombinant Proteins/immunology; Recombinant Proteins/metabolism; Spectrophotometry, Ultraviolet/methods; Steroid 21-Hydroxylase/chemistry; Steroid 21-Hydroxylase/immunology; Steroid 21-Hydroxylase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Addison Disease / Steroid 21-Hydroxylase Limits: Humans Language: En Journal: Eur J Endocrinol Journal subject: ENDOCRINOLOGIA Year: 2005 Document type: Article Country of publication: United kingdom

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