The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein.

Clapéron, Audrey; Rose, Christiane; Gane, Pierre; Collec, Emmanuel; Bertrand, Olivier; Ouimet, Tanja

Clapéron, Audrey; Rose, Christiane; Gane, Pierre; Collec, Emmanuel; Bertrand, Olivier; Ouimet, Tanja.

Affiliation

Clapéron A; INSERM U573, 75014 Paris, France.

J Biol Chem ; 280(22): 21272-83, 2005 Jun 03.

Article in En | MEDLINE | ID: mdl-15769748

Subject(s)

Antigens, Surface/physiology; Blood Proteins/physiology; Metalloproteases/chemistry; Antigens/chemistry; Antigens, Surface/chemistry; Blood Proteins/chemistry; Bone Marrow Cells/metabolism; Brefeldin A/pharmacology; Catalysis; Cell Line; Cell Membrane/metabolism; Cell Separation; Chromatography, High Pressure Liquid; DNA Primers/chemistry; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Erythrocytes/metabolism; Flow Cytometry; Glycoside Hydrolases/metabolism; Glycosylation; Humans; Hydrolysis; K562 Cells; Kinetics; Mass Spectrometry; Metalloendopeptidases/chemistry; Microscopy, Fluorescence; Neurokinin A/chemistry; Peptides/chemistry; Phenotype; Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tachykinins/chemistry; Tachykinins/metabolism; Temperature; Transfection; Zinc/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Proteins / Metalloproteases / Antigens, Surface Type of study: Diagnostic_studies Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: France Country of publication: United States

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