The immunoepidemiology of human hookworm infection.

Quinnell, R J; Bethony, J; Pritchard, D I

Quinnell, R J; Bethony, J; Pritchard, D I.

Affiliation

Quinnell RJ; School of Biology, University of Leeds, Leeds LS2 9JT, UK. r.j.quinnell@leeds.ac.uk

Parasite Immunol ; 26(11-12): 443-54, 2004.

Article in En | MEDLINE | ID: mdl-15771680

ABSTRACT

ABSTRACT

Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.

Subject(s)

Ancylostoma/immunology; Hookworm Infections/epidemiology; Hookworm Infections/immunology; Necator americanus/immunology; Ancylostoma/pathogenicity; Ancylostomiasis/epidemiology; Ancylostomiasis/immunology; Ancylostomiasis/parasitology; Animals; Hookworm Infections/parasitology; Humans; Necator americanus/pathogenicity; Necatoriasis/epidemiology; Necatoriasis/immunology; Necatoriasis/parasitology

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Collection: 01-internacional Database: MEDLINE Main subject: Necator americanus / Hookworm Infections / Ancylostoma Limits: Animals / Humans Language: En Journal: Parasite Immunol Year: 2004 Document type: Article Affiliation country: United kingdom

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