Mitochondrial DNA content is decreased in autosomal dominant optic atrophy.

Kim, J Y; Hwang, J-M; Ko, H S; Seong, M-W; Park, B-J; Park, S S

Kim, J Y; Hwang, J-M; Ko, H S; Seong, M-W; Park, B-J; Park, S S.

Affiliation

Kim JY; Department of Laboratory Medicine, Seoul National University College of Medicine and Seoul National University Hospital Clinical Research Institute, and Seoul Seobu Blood Center, Korean Red Cross, Seoul, Korea.

Neurology ; 64(6): 966-72, 2005 Mar 22.

Article in En | MEDLINE | ID: mdl-15781809

Subject(s)

DNA, Mitochondrial/genetics; GTP Phosphohydrolases/genetics; Nerve Degeneration/genetics; Optic Atrophy, Autosomal Dominant/genetics; Optic Nerve/physiopathology; Adolescent; Adult; Age of Onset; Aged; Alternative Splicing/genetics; Child; Child, Preschool; DNA Mutational Analysis; Energy Metabolism/genetics; Female; Gene Dosage/genetics; Genetic Predisposition to Disease/genetics; Genetic Testing; Humans; Male; Middle Aged; Mitochondria/genetics; Mitochondria/metabolism; Mutation/genetics; Nerve Degeneration/metabolism; Nerve Degeneration/physiopathology; Optic Atrophy, Autosomal Dominant/metabolism; Optic Atrophy, Autosomal Dominant/physiopathology; Optic Nerve/metabolism; Optic Nerve/pathology; Polymorphism, Genetic/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Optic Nerve / DNA, Mitochondrial / Optic Atrophy, Autosomal Dominant / GTP Phosphohydrolases / Nerve Degeneration Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: Neurology Year: 2005 Document type: Article Country of publication: United States

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