Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.
J Clin Endocrinol Metab
; 90(6): 3215-24, 2005 Jun.
Article
in En
| MEDLINE
| ID: mdl-15797954
ABSTRACT
PURPOSE:
To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis.METHODS:
Serum 25(OH)D and PTH were obtained in 1536 community-dwelling women between November 2003 and March 2004. Multivariate logistic regression was used to assess risk factors for suboptimal (<30 ng/ml) 25(OH)D.RESULTS:
Ninety-two percent of study subjects were Caucasian, with a mean age of 71 yr. Thirty-five percent resided at or above latitude 42 degrees north, and 24% resided less than 35 degrees north. Mean (sd) serum 25(OH)D was 30.4 (13.2) ng/ml serum 25(OH)D was less than 20 ng/ml in 18%; less than 25 ng/ml in 36%; and less than 30 ng/ml in 52%. Prevalence of suboptimal 25(OH)D was significantly higher in subjects who took less than 400 vs. 400 IU/d or more vitamin D. There was a significant negative correlation between serum PTH concentrations and 25(OH)D. Risk factors related to vitamin D inadequacy included age, race, body mass index, medications known to affect vitamin D metabolism, vitamin D supplementation, exercise, education, and physician counseling regarding vitamin D.CONCLUSIONS:
More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D Deficiency
/
Osteoporosis, Postmenopausal
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Female
/
Humans
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2005
Document type:
Article
Affiliation country:
United States