Homeostatic activity-dependent paradigm for neurotransmitter specification.
Cell Calcium
; 37(5): 417-23, 2005 May.
Article
in En
| MEDLINE
| ID: mdl-15820389
ABSTRACT
Calcium-signaling plays a central role in specification of the chemical transmitters neurons express, adjusting the numbers of cells that express excitatory and inhibitory transmitters as if to achieve homeostatic regulation of excitability. Here we review the extent to which this activity-dependent regulation is observed for a range of different transmitters. Strikingly the homeostatic paradigm is observed both for classical and for peptide transmitters and in mature as well as in embryonic nervous systems. Transmitter homeostasis adds another dimension to homeostatic regulation of function in the nervous system that includes regulation of levels of voltage-gated ion channels, densities of neurotransmitter receptors, and synapse numbers and strength.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurotransmitter Agents
/
Homeostasis
Limits:
Animals
Language:
En
Journal:
Cell Calcium
Year:
2005
Document type:
Article
Affiliation country:
United States