Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.

Bard-Chapeau, Emilie A; Hevener, Andrea L; Long, Shinong; Zhang, Eric E; Olefsky, Jerrold M; Feng, Gen-Sheng

Bard-Chapeau, Emilie A; Hevener, Andrea L; Long, Shinong; Zhang, Eric E; Olefsky, Jerrold M; Feng, Gen-Sheng.

Affiliation

Bard-Chapeau EA; Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

Nat Med ; 11(5): 567-71, 2005 May.

Article in En | MEDLINE | ID: mdl-15821749

Subject(s)

Insulin/metabolism; Liver/metabolism; Phosphoproteins/metabolism; Signal Transduction/physiology; Adaptor Proteins, Signal Transducing; Animals; Blood Chemical Analysis; Blood Glucose; DNA Primers; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases/metabolism; Genetic Engineering; Glucose Tolerance Test; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Phosphoproteins/genetics; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Signal Transduction / Insulin / Liver Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2005 Document type: Article Affiliation country: United States

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