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Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.
O'Shea, Paul D; Chen, Cheng-yi; Chen, Weirong; Dagneau, Philippe; Frey, Lisa F; Grabowski, Edward J J; Marcantonio, Karen M; Reamer, Robert A; Tan, Lushi; Tillyer, Richard D; Roy, Amélie; Wang, Xin; Zhao, Dalian.
Affiliation
  • O'Shea PD; Department of Process Research, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Québec H9R 4P8, Canada. paul_oshea@merck.com
J Org Chem ; 70(8): 3021-30, 2005 Apr 15.
Article in En | MEDLINE | ID: mdl-15822960
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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / 3',5'-Cyclic-AMP Phosphodiesterases / Combinatorial Chemistry Techniques / Cyclic N-Oxides / Enzyme Inhibitors Language: En Journal: J Org Chem Year: 2005 Document type: Article Affiliation country: Canada Country of publication: United States
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / 3',5'-Cyclic-AMP Phosphodiesterases / Combinatorial Chemistry Techniques / Cyclic N-Oxides / Enzyme Inhibitors Language: En Journal: J Org Chem Year: 2005 Document type: Article Affiliation country: Canada Country of publication: United States