Oral contraceptives and polyp regression in familial adenomatous polyposis.
Gastroenterology
; 128(4): 1077-80, 2005 Apr.
Article
in En
| MEDLINE
| ID: mdl-15825088
ABSTRACT
Epidemiologic and experimental reports suggest that female hormones protect against the development of colorectal cancer, but studies are limited. We describe a patient in the placebo arm of a 4-year primary chemoprevention trial who developed adenomatous polyps and then had eradication of polyps after the administration of oral contraceptives. No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making nonsteroidal anti-inflammatory drug ingestion unlikely as a cause. This report represents the regression of colorectal adenomas with the use of estrogen/progesterone compounds.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenomatous Polyposis Coli
/
Contraceptives, Oral
Type of study:
Clinical_trials
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
Gastroenterology
Year:
2005
Document type:
Article
Affiliation country:
United States