Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.

Li, Hao; Repa, Joyce J; Valasek, Mark A; Beltroy, Eduardo P; Turley, Stephen D; German, Dwight C; Dietschy, John M

Li, Hao; Repa, Joyce J; Valasek, Mark A; Beltroy, Eduardo P; Turley, Stephen D; German, Dwight C; Dietschy, John M.

Affiliation

Li H; Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, Texas 75390-8887, USA.

J Neuropathol Exp Neurol ; 64(4): 323-33, 2005 Apr.

Article in En | MEDLINE | ID: mdl-15835268

Subject(s)

Cholesterol/metabolism; Neurodegenerative Diseases; Neurons/metabolism; Niemann-Pick Diseases; Animals; Body Weight; Cell Death; Cerebellum/cytology; Cerebellum/pathology; Cholesterol, Dietary; Female; Intracellular Signaling Peptides and Proteins; Lipase/genetics; Lipase/metabolism; Lysosomes/enzymology; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Molecular Sequence Data; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/metabolism; Neurodegenerative Diseases/pathology; Neurodegenerative Diseases/physiopathology; Neurons/pathology; Niemann-Pick C1 Protein; Niemann-Pick Diseases/genetics; Niemann-Pick Diseases/metabolism; Niemann-Pick Diseases/pathology; Niemann-Pick Diseases/physiopathology; Proteins/genetics; Proteins/metabolism; RNA, Messenger/metabolism; Survival Rate

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Collection: 01-internacional Database: MEDLINE Main subject: Niemann-Pick Diseases / Cholesterol / Neurodegenerative Diseases / Neurons Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Neuropathol Exp Neurol Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom

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