[The role of peroxisome proliferator-activated receptor gamma in the pathogenesis of diabetes and atheromatosis]. / Rola receptora aktywowanego przez proliferatory peroksysomów gamma w patogenezie cukrzycy i miazdzycy.
Przegl Lek
; 61(12): 1436-9, 2004.
Article
in Pl
| MEDLINE
| ID: mdl-15850344
ABSTRACT
The high risik of cardiovascular diseases in diabetes is connected with wide and premature atheromatosis. It is caused by systemic metabolic disorders like hyperglycaemia, insulin resistance, dyslipidaemia, endothelium dysfunction. This review will discuss the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the pathogenesis diabetes and atheromatosous injury of vessels. PPARgamma is a nuclear transcript factor with a very wide spectrum of biological activities. It influences important risik factors of atheromathosis, especially by patients with metabolic syndrome in diabetes type 2. Thiazolidinediones, which is activators PPARgamma, could be a turning-point in the treatment of diabetic angiopathy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
PPAR gamma
/
Diabetes Mellitus, Type 2
Type of study:
Etiology_studies
Limits:
Humans
Language:
Pl
Journal:
Przegl Lek
Year:
2004
Document type:
Article