On the remarkable antitumor properties of fludelone: how we got there.
Angew Chem Int Ed Engl
; 44(19): 2838-50, 2005 May 06.
Article
in En
| MEDLINE
| ID: mdl-15880547
ABSTRACT
Small-molecule natural products are presumably often biosynthesized with a view to optimizing their ability to bind to strategic proteins or other biomolecular targets. Although the ultimate setting in which a drug must function may be very different, the use of such natural products as lead compounds can serve as a significant head start in the hunt for new agents of clinical value. Herein we reveal the synergistic relationship between chemical synthesis and drug optimization in the context of our research program around the epothilones how synthesis led to the discovery of more-potent epothilone derivatives, and discovery inspired the development of new synthetic routes, thus demonstrating the value of target-directed total synthesis in the quest for new substances of material clinical benefit.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Epothilones
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2005
Document type:
Article
Affiliation country:
United States