New inhibitors of the Tat-TAR RNA interaction found with a "fuzzy" pharmacophore model.

Renner, Steffen; Ludwig, Verena; Boden, Oliver; Scheffer, Ute; Göbel, Michael; Schneider, Gisbert

Renner, Steffen; Ludwig, Verena; Boden, Oliver; Scheffer, Ute; Göbel, Michael; Schneider, Gisbert.

Affiliation

Renner S; Beilstein Endowed Chair for Cheminformatics, Institut für Organische Chemie und Chemische Biologie, Johann-Wolfgang-Goethe-Universität, Marie-Curie-Strasse 11, 60439 Frankfurt am Main, Germany.

Chembiochem ; 6(6): 1119-25, 2005 Jun.

Article in En | MEDLINE | ID: mdl-15883975

Subject(s)

Anti-HIV Agents/pharmacology; Gene Products, tat/antagonists & inhibitors; RNA, Viral/antagonists & inhibitors; Acepromazine/pharmacology; Binding Sites/drug effects; Chlorpromazine/pharmacology; Drug Design; Fluorescence Resonance Energy Transfer; Gene Products, tat/metabolism; HIV-1/chemistry; HIV-1/metabolism; Nucleic Acid Conformation; RNA, Viral/metabolism; Structure-Activity Relationship; tat Gene Products, Human Immunodeficiency Virus

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Collection: 01-internacional Database: MEDLINE Main subject: RNA, Viral / Gene Products, tat / Anti-HIV Agents Type of study: Prognostic_studies Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2005 Document type: Article Affiliation country: Germany

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