AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.

Wedge, Stephen R; Kendrew, Jane; Hennequin, Laurent F; Valentine, Paula J; Barry, Simon T; Brave, Sandra R; Smith, Neil R; James, Neil H; Dukes, Michael; Curwen, Jon O; Chester, Rosemary; Jackson, Janet A; Boffey, Sarah J; Kilburn, Lyndsey L; Barnett, Sharon; Richmond, Graham H P; Wadsworth, Peter F; Walker, Mike; Bigley, Alison L; Taylor, Sian T; Cooper, Lee; Beck, Sarah; Jürgensmeier, Juliane M; Ogilvie, Donald J

Wedge, Stephen R; Kendrew, Jane; Hennequin, Laurent F; Valentine, Paula J; Barry, Simon T; Brave, Sandra R; Smith, Neil R; James, Neil H; Dukes, Michael; Curwen, Jon O; Chester, Rosemary; Jackson, Janet A; Boffey, Sarah J; Kilburn, Lyndsey L; Barnett, Sharon; Richmond, Graham H P; Wadsworth, Peter F; Walker, Mike; Bigley, Alison L; Taylor, Sian T; Cooper, Lee; Beck, Sarah; Jürgensmeier, Juliane M; Ogilvie, Donald J.

Affiliation

Wedge SR; Cancer Bioscience, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom. steve.wedge@astrazeneca.com

Cancer Res ; 65(10): 4389-400, 2005 May 15.

Article in En | MEDLINE | ID: mdl-15899831

Subject(s)

Neoplasms/drug therapy; Neoplasms/enzymology; Protein Kinase Inhibitors/pharmacology; Quinazolines/pharmacology; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Administration, Oral; Animals; Biological Availability; Bone Development/drug effects; Cell Proliferation/drug effects; Corpus Luteum/drug effects; Corpus Luteum/growth & development; Endothelial Cells/drug effects; Endothelial Cells/enzymology; Endothelial Cells/metabolism; Extracellular Matrix Proteins; Female; Humans; Mice; Myosin Heavy Chains; Neoplasms/blood supply; Neoplasms/pathology; Nonmuscle Myosin Type IIB; Phosphorylation/drug effects; Protein Kinase Inhibitors/pharmacokinetics; Proteins/antagonists & inhibitors; Quinazolines/pharmacokinetics; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2/metabolism; Vascular Endothelial Growth Factor Receptor-3/antagonists & inhibitors; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Vascular Endothelial Growth Factor Receptor-2 / Protein Kinase Inhibitors / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United States

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