Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.
FEBS Lett
; 579(14): 3055-62, 2005 Jun 06.
Article
in En
| MEDLINE
| ID: mdl-15907845
ABSTRACT
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Products, tat
/
Cytokines
/
EIF-2 Kinase
/
MAP Kinase Signaling System
/
Extracellular Signal-Regulated MAP Kinases
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
2005
Document type:
Article
Affiliation country:
China